Definition: Acetylizing refers to a chemical reaction that occurs in the human body where acetylcholinesterase enzyme, which helps to synthesize acetyl choline into acetylcholine in the brain, undergoes a conversion from its original active form (the acetyl group) into a more stable form. This change can be termed as 'acetylizing' because it involves the removal of acetyl groups from the acetyl choline molecule. The specific chemical reaction involved is called "Acetyl-ACPase Reaction" or "Acetylcholinesterase-ACPase Reaction." It occurs during the process of synaptic transmission, where acetylcholine molecules are produced and transported to the end of the nerve fiber. The acetyl groups attached to the acetylcholine molecules are removed from it via this reaction. This results in the synthesis of acetylcholine into a form more stable. Acetylizing has many therapeutic applications such as treating Parkinson's disease, Alzheimer's disease, and stroke. It is also used in neurodegenerative disorders like Alzheimer's dementia where the acetyl groups attached to acetylcholine molecules are removed causing neuronal loss leading to cognitive impairment.
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