Definition: Acidosis is a condition characterized by the buildup or accumulation of acids in cells, tissues or fluids. The term "acidosis" was first used in 1879 by Charles F. Brown. This disease occurs when the body is unable to neutralize its own acid production (acidemia) or has an excessive acid secretion and/or a deficiency in the absorption of bicarbonate ions (bicarbonate ionosis). The body then seeks ways to maintain its pH, usually by releasing carbonic anhydrase into the blood, which is responsible for removing excess hydrogen ions. Acidosis can be caused by a variety of causes including: 1.

Severe burns:

When blood vessels are injured and the acid produced from the burn's enzymes leaches into the bloodstream, it can cause acidosis. 2.

Vaccination reactions:

Certain drugs or vaccines that neutralize acid production (such as Tdap) can lead to severe acidosis if used improperly or in large doses. 3.

Cancer treatments:

Radiation therapy can decrease blood pH and increase levels of carbonic anhydrase, which is involved in the elimination of excess hydrogen ions, leading to acidosis. 4.

Nephrogenic diabetes insipidus (kidney disease):

In this condition, low blood potassium results from electrolyte imbalance due to decreased bicarbonate production by the kidneys. 5.

Pulmonary edema:

Kidneys can cause fluid buildup in the lungs and cause a decrease in blood volume and thus increased thirst. 6.

Nutritional acidosis:

A deficiency of essential fatty acids or vitamins can lead to high levels of pepsin (a digestive enzyme) that depletes stomach acid. Acidosis is often treated with medication to lower the amount of excess acids produced, such as intravenous fluids or antibiotics. It's important to monitor acid levels closely and take action promptly if symptoms persist or worsen.

acidosis