Definition: Acromegaly or acromegitis is a rare, chronic, and often progressive disease in which the adrenal gland grows larger, leading to obesity and muscle weakness. The underlying cause of this condition is generally thought to be due to an increase in circulating growth hormone, also known as prolactin, but it may also be caused by other causes such as diabetes or certain medications. There are two types of acromegaly: primary acromegaly, which is a congenital disorder that affects only the pituitary gland and does not cause additional symptoms; and secondary acromegaly, which is an adult-onset condition that typically develops in older individuals due to hormonal imbalances caused by various factors such as obesity or diabetes. The symptoms of acromegaly can include obesity, facial growth (also known as "waterline"), increased muscle mass, and decreased bone density. The disease can also cause mental retardation in some cases. Treatment for acromegaly includes a combination of medical therapy and lifestyle changes to manage the symptoms and prevent complications such as diabetes-related kidney disease or heart problems.

acromegalic