Definition: Actinodrome is a small, highly branched organ in animals that plays a crucial role as a site for protein synthesis. In humans, it is located at the base of the skeletal muscle fiber (the sarcoplasmic reticulum). The actin and myosin filaments (myofilins) are embedded within the actinodrome. There are approximately 100 actin and 35 myosin filaments in the actinodrome, which allows for a large-scale contraction of muscle fibers. Myofilins move between the actin and myosin filaments to form filopodia, which then enter the myofibril (myofibrillary) cell membrane. This process is called microfilament assembly and it forms a network of filopods within the actinodrome. These filopods are highly branched, making them capable of forming complex structures in muscle fibers.
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