Definition: The term 'acetonaemia' means a deficiency in the absorption or production of acetic acid, an amide of alanine that plays important roles in metabolic pathways.
This condition may occur due to various conditions such as liver disease, alcohol abuse, malabsorption from intestinal surgery, malnutrition, and certain medications. The exact cause of this condition is not fully known, but it has been linked to a deficiency in the production of the enzyme alanine-aminotransferase (ALT), which is responsible for the conversion of alanine into acetic acid.
Acetic acid is a key player in many metabolic pathways, including those involved with muscle contraction, neurotransmission, and energy metabolism. The inability to properly absorb or produce this acid can cause various health issues, including liver damage, malabsorption from the gut, and reduced absorption of fat-soluble vitamins such as vitamin B12.
In some cases, acetonaemia may be managed by dietary adjustments, medications for enzyme deficiency (such as probiotics or bile salts), or through lifestyle changes such as weight loss. The exact management of this condition varies depending on the underlying cause and is highly individualized.
acetonaemia