Definition: Acinetin (also known as 4-aminophenylalanine, 4-aminomethylphenylalanine) is a small molecule antibiotic produced by Acinetobacter baumannii. It is a non-metabolic active prodrug that converts to a bacteriocin. The term 'acinetinan' is derived from the Greek words 'aconitina' and 'anina'. The word 'aconitina' means 'little seed', which fits the role of 4-aminophenylalanine. The word 'anina' translates to 'antibiotic'. Acinetin belongs to the family of small organic molecules, known as aminocoumarins. These compounds are classified as natural products with an antiparasitic and antimicrobial activity. Acinetinan is a type of prodrug that converts to bacteriocin and is released into the bloodstream via the lungs or through mouth if it is swallowed directly. The bacteriocin, which is not produced by A. baumannii, is used for treating bacterial infections such as pneumonia, meningitis, and urinary tract infections. Acinetinan's role in pathogen infection is crucial to its antimicrobial activity. It can be found naturally in a wide variety of bacteria including A. baumannii, E. coli, Pseudomonas aeruginosa, and S. aureus.
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