Definition: Adenine, a nucleotide in DNA, is a sugar-phosphate linkage molecule that links two carbon-carbon bonds between adenine (A) nucleotides. The structure of adenine is a tetrahedral shape, with the nitrogen atom on one end and the three phosphodiester linkers on the other two ends. The ring around the nitrogen atom contains six double-bonded pairs of nitrogen atoms, which are linked to each other by hydrogen bonds. Adenin is a very reactive nucleotide because it is easily oxidized to adenine and acetyladenine (also called pyrimidine diphosphate) or to thymine. In DNA, adenine is converted into purine in the presence of uracil, while thymine becomes adenine in the absence of uracil. Adenin binds to DNA by hydrogen bonds, which are strong but reversible. The two nitrogen atoms in a double bond can be bonded together or separated by a phosphodiester link, resulting in either an adenine-adenine or purine-thymine pairing. This binding allows adenine to interact with DNA to form the major structural component of DNA. Adenin is the only nucleotide that is completely unpaired; it is not paired with any other nucleotide except for uracil and pyrimidine diphosphate (7-aminotrimethylsulfonylphosphonic acid) (ATP). Adenin can be produced synthetically through an enzyme called adenine dehydrogenase, which catalyzes the addition of a hydroxyl group to adenine. This process is used in many biochemical applications, including genetic modification and DNA repair mechanisms. Overall, adenine plays a crucial role in DNA structure, function, and regulation, contributing to the integrity and stability of cellular life.