Definition: An oxidation reaction, a chemical reaction that involves the loss or gain of electrons in a compound. Definition: The oxidation state of an atom is defined as the number of protons it gains when electrons are added to its atoms. For example, in the reaction 4Fe2++3O2 -> 2Fe3+ + 2SO42-, two electrons are added from Fe2+, resulting in a net increase in the oxidation state of Fe. An oxide is a compound that contains at least one element that loses an electron when it reacts with another element. They can include oxides of iron, sulfur, and calcium, to name a few examples.