Definition: In Christian theology, antispasmodics are medications used to relieve spasm or spasms due to tightness or pain in the muscles. Definition: Antispasmodic medicines are medication that can help treat spasm or spasms caused by tightness in the muscles and pain. Example: Antispasmodics may include medications such as ibuprofen, aspirin, and nonsteroidal anti-inflammatory drugs (NSAIDs) that have been shown to reduce muscle tension.