Definition: Arteriolosclerosis is a condition characterized by abnormal blood vessels in the arteries leading to brain and spinal cord, causing blockage that can lead to stroke or other brain-related problems. Detailed definition: Arteriolosclerosis involves abnormal blood vessel growths or narrowing within the capillaries of the arteries, which can cause blood flow issues and potentially result in ischemia (loss of oxygen and nutrients) throughout the body's various organs and systems.